North Central College - Naperville, IL

Animal Subjects Guidelines

Approval of animal research. The criteria for the approval of animal research are adapted from the Public Health Service Policy on Humane Care and Use of Laboratory Animals, amended August 2002
(see <> ).  Animal research conducted at North Central College shall meet the criteria for ethical animal research contained in Table 3.

Table 3.  Criteria for approval of animal research*

(adapted from the PHS Policy on Humane Use and Care of Laboratory Animals).

I. The transportation, care, and use of animals should be in accordance with the Animal Welfare Act (7 U.S.C. 2131 et. seq.) <> and other applicable Federal laws, guidelines, and policies.

II. Procedures involving animals should be designed and performed with due consideration of their relevance to human or animal health, the advancement of knowledge, or the good of society.

III. The animals selected for a procedure should be of an appropriate species and quality and the minimum number required to obtain valid results. Methods such as mathematical models, computer simulation, and in vitro biological systems should be considered.

IV. Proper use of animals, including the avoidance or minimization of discomfort, distress, and pain when consistent with sound scientific practices, is imperative. Unless the contrary is established, investigators should consider that procedures that cause pain or distress in human beings may cause pain or distress in other animals.

V. Procedures with animals that may cause more than momentary or slight pain or distress should be performed with appropriate sedation, analgesia, or anesthesia. Surgical or other painful procedures should not be performed on unanesthetized animals paralyzed by chemical agents.

VI. Animals that would otherwise suffer severe or chronic pain or distress that cannot be relieved should be painlessly killed at the end of the procedure or, if appropriate, during the procedure.

VII. Euthanasia shall be accomplished in a humane manner, appropriate for the species, and in accordance with the recommendations of the American Veterinary Medical Association (AVMA) Panel on Euthanasia.

VIII. The living conditions of animals should be appropriate for their species and contribute to their health and comfort. Normally, the housing, feeding, and care of all animals used for biomedical purposes must be directed by a veterinarian or other scientist trained and experienced in the proper care, handling, and use of the species being maintained or studied. In any case, veterinary care shall be provided as indicated.

IX. Investigators and other personnel shall be appropriately qualified and experienced for conducting procedures on living animals. Adequate arrangements shall be made for their in-service training, including the proper and humane care and use of laboratory animals.

X.  Investigators conducting field research should disturb their populations as little as possible - consistent with the goals of the research.  Every effort should be made to minimize potential harmful effects of the study on the population and on other plant and animal species in the area.  Research on endangered species requires particular justification, and should not be conducted unless all requisite permits are obtained.

XI. Where exceptions are required in relation to the provisions of these Principles, the decisions should not rest with the investigators directly concerned but should be made, with due regard to Principle II, by an appropriate review group such as an institutional animal care and use committee. Such exceptions should not be made solely for the purposes of teaching or demonstration.

*For guidance throughout these Principles, the reader is referred to the Guide for the Care and Use of Laboratory Animals  prepared by the Institute of Laboratory Animal Resources, National Academy of Sciences.

Consequences for Non-Compliance with this Protocol

            All North Central College employees who conduct or supervise research using human research participants or animal subjects are responsible for being familiar with and following this protocol.  Faculty supervisors are responsible for ensuring that their students follow this protocol.  Faculty researchers who do not follow this protocol will be referred in writing to the Dean of the Faculty for appropriate disciplinary action, and the Committee Chair will draft a letter to the Faculty Personnel Committee documenting this noncompliance.  Non-complaint researchers who are not faculty members will be referred to their immediate supervisors for disciplinary action.